About
Aims
The Rosenfeld Lab employs emerging molecular technologies to develop new diagnostic approaches. Our focus is on circulating tumour DNA (ctDNA) as a noninvasive modality to assess evolution of solid malignancies. This is DNA originating from cancer cells, carrying tumour-specific genomic alterations, that is present as short cell-free fragments in body fluids such as blood plasma. ctDNA can be collected noninvasively via blood samples and has the potential to be immensely informative.
Recent Publications
Wan JCM, Heider K, Gale D, Murphy S, Fisher E, Mouliere F, Ruiz-Valdepenas A, Santonja A, Morris J, Chandrananda D, Marshall A, Gill AB, Chan PY, Barker E, Young G, Cooper WN, Hudecova I, Marass F, Mair R, Brindle KM, Stewart GD, Abraham JE, Caldas C, Rassl DM, Rintoul RC, Alifrangis C, Middleton MR, Gallagher FA, Parkinson C, Durrani A, McDermott U, Smith CG, Massie CE, Corrie PG and Rosenfeld N. ctDNA monitoring using patient-specific sequencing and integration of variant reads Science Translational Medicine 17 Jun 2020: Vol. 12, Issue 548, eaaz8084 DOI: 10.1126/scitranslmed.aaz8084
Mouliere F, Chandrananda D, Piskorz AM, Moore EK, Morris J, Ahlborn LB, Mair R, Goranova T, Marass F, Heider K, Wan JCM, Supernat A, Hudecova I, Gounaris I, Ros S, Jimenez-Linan M, Garcia-Corbacho J, Patel K, Østrup O, Murphy S, Eldridge MD, Gale D, Stewart GD, Burge J, Cooper WN, van der Heijden MS, Massie CE, Watts C, Corrie P, Pacey S, Brindle KM, Baird RD, Mau-Sørensen M, Parkinson CA, Smith CG, Brenton JD and Rosenfeld N. Enhanced detection of circulating tumor DNA by fragment size analysis Science Translational Medicine 07 Nov 2018: Vol. 10, Issue 466, eaat4921 DOI: 10.1126/scitranslmed.aat4921
Wan JCM, Massie C, Garcia-Corbacho J, Mouliere F, Brenton JD, Caldas C, Pacey S, Baird S, Rosenfeld N. Liquid biopsies come of age: towards implementation of circulating tumour DNA Nat Rev Cancer. 2017 Apr;17(4):223-238. doi: 10.1038/nrc.2017.7 Epub 2017 Feb 24.
See all publications
The Rosenfeld Lab employs emerging molecular technologies to develop new diagnostic approaches. Our focus is on circulating tumour DNA (ctDNA) as a noninvasive modality to assess evolution of solid malignancies. This is DNA originating from cancer cells, carrying tumour-specific genomic alterations, that is present as short cell-free fragments in body fluids such as blood plasma. ctDNA can be collected noninvasively via blood samples and has the potential to be immensely informative.
Recent Publications
Wan JCM, Heider K, Gale D, Murphy S, Fisher E, Mouliere F, Ruiz-Valdepenas A, Santonja A, Morris J, Chandrananda D, Marshall A, Gill AB, Chan PY, Barker E, Young G, Cooper WN, Hudecova I, Marass F, Mair R, Brindle KM, Stewart GD, Abraham JE, Caldas C, Rassl DM, Rintoul RC, Alifrangis C, Middleton MR, Gallagher FA, Parkinson C, Durrani A, McDermott U, Smith CG, Massie CE, Corrie PG and Rosenfeld N. ctDNA monitoring using patient-specific sequencing and integration of variant reads Science Translational Medicine 17 Jun 2020: Vol. 12, Issue 548, eaaz8084 DOI: 10.1126/scitranslmed.aaz8084
Mouliere F, Chandrananda D, Piskorz AM, Moore EK, Morris J, Ahlborn LB, Mair R, Goranova T, Marass F, Heider K, Wan JCM, Supernat A, Hudecova I, Gounaris I, Ros S, Jimenez-Linan M, Garcia-Corbacho J, Patel K, Østrup O, Murphy S, Eldridge MD, Gale D, Stewart GD, Burge J, Cooper WN, van der Heijden MS, Massie CE, Watts C, Corrie P, Pacey S, Brindle KM, Baird RD, Mau-Sørensen M, Parkinson CA, Smith CG, Brenton JD and Rosenfeld N. Enhanced detection of circulating tumor DNA by fragment size analysis Science Translational Medicine 07 Nov 2018: Vol. 10, Issue 466, eaat4921 DOI: 10.1126/scitranslmed.aat4921
Wan JCM, Massie C, Garcia-Corbacho J, Mouliere F, Brenton JD, Caldas C, Pacey S, Baird S, Rosenfeld N. Liquid biopsies come of age: towards implementation of circulating tumour DNA Nat Rev Cancer. 2017 Apr;17(4):223-238. doi: 10.1038/nrc.2017.7 Epub 2017 Feb 24.
See all publications